BRCA somatic mutations and epigenetic BRCA modifications in serous ovarian cancer Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Wednesday, April 06, 2016

BRCA somatic mutations and epigenetic BRCA modifications in serous ovarian cancer



1) abstract 

2) open access - pdf 

 Key Message: "This article summarises the evolving role and challenges of somatic BRCA mutations and BRCA methylation in ovarian cancer"

Conclusion
The activity of PARP inhibitors is now beyond germline BRCA mutation-associated ovarian cancer and more widely applicable to HRD. The therapeutic implications of BRCA epigenetic modifications are not clear...... 
 
 (HRD: homologous combination deficiency)

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