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open access PDQ Cancer Information Summaries
Ovarian GCTs
Ovarian
GCTs occur primarily in adolescent and young adult females. While most
ovarian GCTs are benign mature teratomas, a heterogeneous group of
malignant GCTs, including immature teratomas, dysgerminomas, yolk sac
tumors, and mixed GCTs, do occur in females. The malignant ovarian GCT
commonly shows increased copies of the short arm of chromosome 12.[39]
Patients
with pediatric ovarian GCTs have an excellent prognosis. One series of
66 patients monitored for more than 44 years reported recurrence rates
of 4.5% and mortality rates of 3%.[40]
(Refer to the PDQ summary on Ovarian Germ Cell Tumors Treatment for more information.)
Table 1. Incidence of Extracranial Germ Cell Tumors by Age Group and Gender (per 106 population)a
0–4 years | 5–9 years | 10–14 years | 15–19 years | |||||
---|---|---|---|---|---|---|---|---|
Males | 7 | 0.3 | 1.4 | 31 | ||||
Females | 5.8 | 2.4 | 7.8 | 25.3 |
Table 3. Histology of Malignant Germ Cell Tumors in Adolescents and Young Adultsa
Malignant Germ Cell Elements | Location |
---|---|
Seminoma | T |
Dysgerminoma | O |
Germinoma | E |
Yolk sac tumor (endodermal sinus tumor) | E, O, T |
Choriocarcinoma | E, O, T |
Embryonal carcinoma | E, T |
Mixed germ cell tumors | E, O, T |
- E = extragonadal; O = ovarian; T = testicular.
- aModified from Perlman et al.[25]
Adolescent
and young adult males present with more germinomas (testicular and
mediastinal seminomas), and females present with more ovarian
dysgerminomas.
- aRates are per 1 million children from 1986 to 1995 for the nine Surveillance, Epidemiology, and End Results regions plus Los Angeles.
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