Clinicopathologic characteristics and survival of patients with gyn malignancies metastatic to the brain

abstract

OBJECTIVE: 

 No standardized treatment strategies exist for patients with gynecologic malignancies complicated by brain metastases.....

METHODS:

This retrospective cohort study included 100 gynecologic cancer patients with brain metastases treated at our institution between January 1990 and June 2009....
 

RESULTS:

On univariate analysis, primary ovarian disease, CA-125<81 units/mL at brain metastases diagnosis, and isolated versus multi-focal metastases were all associated with longer survival.....

CONCLUSIONS:

Multi-modality therapy may lead to improved clinical outcomes, and VEGF therapy should be investigated in treatment of brain metastases.