abstract:
Clinicopathologic features of ovarian neoplasms with emphasis on borderline ovarian tumors: an institutional perspective
BACKGROUND:
Ovarian
cancer is the most lethal gynecologic malignancy and it represents
third most common malignancy in Karachi (after breast and oral cancer).
Due to lack of well established cancer registry in our country, changing
trends of ovarian tumors has not been determined. Therefore we aimed to
establish the current trends and classification of ovarian tumors in
our setup according to latest WHO guidelines.
METHODS:
We
retrospectively analyzed 162 cases of ovarian tumors that underwent
surgical resection from January 2009 till December 2014. Specimens were
received in histopathology department, Liaquat National hospital and
cases were examined by senior histopathologists and classified according
to latest WHO guidelines. Various histopathologic parameters including
capsular invasion, omental and lymph node meatstasis along with uterine
and fallopian tube involvement were determined apart from tumor type and
grade.
RESULTS:
Mean
age at diagnosis was 35.8 years (± 15.5). surface epithelial tumors
were most common, 109 cases (67.2 %) followed by germ cell tumors, 44
cases (27.1 %) and sex cord stromal tumors, 8 cases (4.9 %). Serous
tumors were most common surface epithelial tumors with 90 % benign
morphology. On the other hand, mucinous tumors showed a higher
percentage of borderline and malignant features (16.7 and 14.6 %
respectively). Higher incidence of capsular invasion and omental
metastasis was noted in endometroid and serous carcinoma compared to
mucinous tumors.
CONCLUSIONS:
We
noted a higher frequency of young age ovarian cancers in our set up.
Serous and endometroid carcinomas were found to be associated with
adverse prognostic factors like capsular invasion and omental
metastasis. Moreover a significantly higher proportion of ovarian tumors
constitute mucinous histology including borderline tumors. Whether this
represents a changing trend towards biology of these tumors in this
part of the world needs to be uncovered by further studies.
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