abstract
OBJECTIVE:
To
investigate the role of previous gynecologic surgery, hormone use, and
use of non-steroidal anti-inflammatory drugs on the risk of type 1 and
type 2 ovarian cancer.
METHODS:
We
utilized data collected for the Prostate, Lung, Colorectal, and Ovarian
cancer screening trial. All diagnosed ovarian cancers were divided into
three groups: type 1, endometrioid, clear cell, mucinous, low grade
serous, and low grade adenocarcinoma/not otherwise specified (NOS); type
2, high grade serous, undifferentiated, carcinosarcoma, and high grade
adenocarcinoma/NOS; and other: adenocarcinoma with grade or histology
not specified, borderline tumors, granulosa cell tumors. The odds ratios
for type 1, type 2, and other ovarian cancers were assessed with regard
to historical information for specific risk factors.
RESULTS:
Ibuprofen
use was associated with a decrease in risk for type 1 ovarian cancer.
Tubal ligation and oral contraceptive use were associated with a
decrease in risk for type 2 ovarian cancer. A history of ectopic
pregnancy was associated with a decreased risk for all ovarian cancers
by almost 70%.
CONCLUSION:
These
findings support the hypothesis that carcinogenic pathways for type 1
and type 2 ovarian cancer are different and distinct. The marked
reduction in all ovarian cancer risk noted with a history of ectopic
pregnancy and salpingectomy implies that the fallopian tube plays a key
role in carcinogenesis for both type 1 and type 2 ovarian cancer.
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