ELITE Provides Reassurance About Estrogen in Early Menopause (not surgical menipause)

medscape

In terms of the clinical implications, based on this trial we can't say that hormone therapy should now be used for prevention of heart disease and other chronic disease events in younger women, because the trial used a surrogate endpoint and there could be other effects of hormone therapy. There is a very complex balance of benefits and risks in terms of venous thrombosis, stroke, breast cancer, and other outcomes.
However, this trial does provide further reassurance about the use of estrogen for the treatment of moderate to severe hot flashes, night sweats, and other menopausal symptoms in early menopause, as well as further evidence that concerns about coronary risk should not be used as a reason for denying hormone therapy treatment to women in early menopause who have these symptoms and are otherwise appropriate candidates for treatment.