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open access
Objective: Most patients with epithelial ovarian
cancer will experience a recurrence; currently, there is no cure. In
patients with platinum-sensitive disease (platinum-free interval >6
months), a combination similar to that used as frontline therapy
(carboplatin and paclitaxel) is recommended. However, it is associated
with a high incidence (20%) of neurotoxicity. This study evaluated the
efficacy and toxicity of combination docetaxel/carboplatin therapy in
patients with platinum-sensitive recurrent ovarian cancer.
Methods:
Forty patients with recurrent, histologically proven ovarian, fallopian
tube, or primary peritoneal cancer were enrolled in this phase 2 trial.
The study protocol included combination therapy with docetaxel, 30 mg/m2,
on days 1 and 8, and carboplatin, area under the curve 5, on day 1,
every 21 days. Twenty received the classical paclitaxel/carboplatin
regimen (control group), and another 20 received the modified
docetaxel/carboplatin protocol (study group).
Results:
Median follow-up was 78 months for the study group and 62 months for
the control group. The study group had a higher overall response rate
compared to controls: 80% and 30%, respectively (P = 0.004;
relative risk, 9.3; 95% confidence interval, 2.18–39.96). Complete
response was achieved in 60% and 25%, respectively (P = 0.054). The study group patients showed a superior 2-year survival rate of 75% compared with the 35% of the controls (P
= 0.011; relative risk, 5.57; 95% confidence interval, 1.47–21.56).
Hematological and neurological toxicity rates did not differ between the
groups (P = 0.451 and P = 0.605, respectively).
Conclusions: Patients with recurrent ovarian cancer
who received the modified docetaxel/carboplatin regimen had higher
overall response and survival rates compared to those who had the
paclitaxel/carboplatin regimen, with no difference in toxicity. Future
larger studies should focus on strategies to compare this regimen to the
current standard, with an emphasis on quality of life.
Ovarian cancer is the most common cause of death among women with gynecological malignancies.1
Most patients with epithelial ovarian cancer have a satisfactory
initial clinical response to aggressive cytoreductive surgery followed
by combination chemotherapy; however, unfortunately, this usually does
not lead to cure. Most patients (>80%) will experience a recurrence.2
At present, randomized studies support the use of
single-agent chemotherapy for recurrent platinum-resistant ovarian
cancer (platinum-free interval ≤6 months). Although combination
therapies are associated with somewhat higher response rates, they are
more toxic, and no regimen has produced a survival benefit compared to
single-agent treatment.3....
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