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Immune checkpoint inhibition in ovarian cancer
Navigate This Article
- Top
- Abstract
- Introduction
- The clinical significance of the local immune status in ovarian cancer
- The B7/CTLA-4 signal
- B7/CTLA-4 signal inhibitors
- PD-1/PD-L1 ligand signaling
- PD-1/PD-L1 signaling in pre-clinical cancer models
- PD-1/PD-L1 signaling in clinical studies of cancer
- Clinical applications of PD-1 inhibitors in cancer
- Clinical applications of PD-1 inhibitors in ovarian cancer
- Clinical issues related to PD-1 inhibitors for ovarian cancer
- Conclusions
- Funding
- Acknowledgements
- References
The early phase of clinical trials of immune checkpoint inhibitors for ovarian cancer have shown the manageable safety profile (17–20) and have demonstrated a dramatic durable anti-tumor response in a certain population of the patients with a 1-year schedule of nivolumab treatment, following no adjuvant anti-tumor treatment (89). Therefore, not only to explore the predictive biomarkers of responders and to find a good combination therapy but also to conduct a clinical trial to decide the maximum anti-tumor effect with a minimum treatment period of immune checkpoint inhibitors may be a next turning point to enhance the value of immune checkpoint inhibitors for ovarian cancer.
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