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abstract
Background: Complete cytoreduction is the
most important prognostic factor in ovarian cancer. However, there exist
conflicting
data on whether the removal of microscopic tumor
metastasis in macroscopically unsuspicious retroperitoneal lymph nodes
is
beneficial.
Patients and Methods: Ovarian cancer
tissues and tissues from lymph node metastasis of 30 patients with FIGO
IIIC
or IV disease undergoing neoadjuvant chemotherapy
(NACT) were obtained and assessed using a validated regression score.
Histopathological
markers, size of largest tumor focus, and overall
score were evaluated in lymph node and ovarian tissue. Regression and
known
prognostic factors were analyzed for influence on
survival.
Results: No difference in the overall score between lymph
nodes
and ovarian tissue was shown, however, single
parameters such as fibrosis and pattern of tumor infiltration, were
significantly
different.
Conclusion: The pattern of tumor
regression in lymph nodes and ovarian tissue are of prognostic value.
Lymph node
dissection even of unsuspicious nodes should,
therefore, be performed.
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