Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Saturday, April 30, 2016

Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium



open access (technical)

 In summary, this study reveals a distinctive role for PAX8 in the ovary compared to the fallopian tube that increases migration, proliferation, and EMT. These findings highlight the importance of deciphering a tumor’s cell of origin because of the unique pathways that are deregulated depending on a tumor’s progenitor cell. Yet despite the unique role of PAX8 in the ovary compared to the fallopian tube, these findings suggest HGSC cells are reliant on PAX8.

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