Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium

open access (technical)

 In summary, this study reveals a distinctive role for PAX8 in the ovary compared to the fallopian tube that increases migration, proliferation, and EMT. These findings highlight the importance of deciphering a tumor’s cell of origin because of the unique pathways that are deregulated depending on a tumor’s progenitor cell. Yet despite the unique role of PAX8 in the ovary compared to the fallopian tube, these findings suggest HGSC cells are reliant on PAX8.