open access: Characteristics of 10-year survivors of high-grade serous ovarian carcinoma

Blogger's Note: previously posted as abstract

open access

 Highlights

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Ovarian cancer survivors who live for 10 or more years comprise a heterogeneous patient population with and without recurrent disease.

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Long-term survivors may have suboptimal cytoreduction or short platinum free intervals.

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BRCA1 and BRCA2 germline mutations appear common among long-term survivors.

Objective

High-grade serous carcinoma (HGSC) generally presents at an advanced stage with poor long-term (LT) survival. Here we describe clinical features found in women surviving HGSC for ten or more years.

Methods

A multi-center research consortium was established between five participating academic centers. Patient selection criteria included high-grade serous ovarian, fallopian tube, or peritoneal carcinoma with at least ten years of follow up. Non-serous, borderline tumors and low-grade serous subtypes were excluded......

(Blogger Notes: some key items)

 median age of 57 years (range 37–84 years)

All three patients with liver metastases remained progression free for more than 10 years and have not developed recurrence.

 The median progression-free survival (PFS) of the entire cohort was 147 months. Twenty-one (11.2%) patients had one recurrence during the follow-up interval, 19 (10.1%) recurred twice, and 60 (31.9%) suffered from more than two recurrences, with 13 patients having more than 10 reported recurrences.

 There were eight patients with stage IV disease who did not experience any recurrence of their disease after initial treatment.