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open access
Histology (n) Serous 582 Other 189
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Ovarian cancer patients from a 6-site study between 1994 and 2010 were included.
To date, no studies have examined effects of SSRIs among patients
already diagnosed with ovarian cancer and the influence SSRIs may have
on survival and disease progression in these patients. Moreover, no
studies have explored the effect of 5-HT or SSRIs on ovarian neoplastic
cell growth. To address these knowledge gaps, we characterized 5-HT
receptor expression in ovarian cancer cells and investigated the
functional and biological roles of 5-HT using in vitro and in vivo
models. In addition, this multicenter study examined effects of SSRIs
on survival and disease progression in patients diagnosed with
epithelial ovarian cancer.....
Patient characteristics
Demographic and clinical characteristics of the sample are listed in Table 1.
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