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abstract
Summary
Renal cell
carcinoma (RCC), the most common type of kidney cancer in adult, rarely
metastasizes to the ovary or fallopian tube, and most cases published
in the literature were case reports. Herein, we describe the
clinicopathological features of 9 cases of RCC metastatic to the ovary
(n = 8) or the fallopian tube (n = 1). The patients' age at the onset of
primary renal tumor was available in 8 patients, ranging from 37 to 73
years (mean, 51 years; median, 50 years). Ovarian metastasis was
detected prior to or concurrently with the primary renal tumors in 3
patients, and after the diagnosis of renal tumors in 6 patients. The
histotypes of the RCCs were clear cell (n = 7), chromophobe (n = 1), and
unclassified (n = 1). Immunohistochemical stainings were performed on
the sections containing metastatic tumors in 4 cases. Interestingly,
pagetoid intraepithelial spread in the tubal mucosa was observed in the
case of RCC metastatic to the fallopian tube. Among the 8 patients with
follow-up data, 5 died of disease and 3 were alive with disease, with a
follow-up period ranging from 3.7 months to 17 years (mean, 77 months;
median, 53 months) after the diagnosis of primary kidney tumors.
Diagnostically, metastatic RCC may mimic primary ovarian tumors
clinically, morphologically, or immunophenotypically. Pathologists
should also keep in mind that both ovarian and kidney tumors express
PAX8 and PAX2, the markers commonly used to diagnose metastatic RCC. In
addition, chromophobe RCC only rarely metastasizes, but it can be a
diagnostic challenge when it metastasizes to the ovary.
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