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Friday, April 15, 2016

Scientist identifies mechanism underlying peripheral neuropathy


 Scientist identifies mechanism underlying peripheral neuropathy
Discovery raises prospect of treatments for common painful condition Date: April 14, 2016

  Rieger conducted her research in zebrafish exposed to paclitaxel, a chemotherapeutic agent used for ovarian, breast, lung, pancreatic and other cancers. Paclitaxel-induced peripheral neuropathy affects the majority of treated patients; however, those who are most severely affected (about 30 percent) have to terminate chemotherapy or reduce the dose because of this condition, which can impact cancer survival.
Journal Reference:
  1. Thomas S. Lisse, Leah J. Middleton, Adriana D. Pellegrini, Paige B. Martin, Emily L. Spaulding, Olivia Lopes, Elizabeth A. Brochu, Erin V. Carter, Ashley Waldron, Sandra Rieger. Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proceedings of the National Academy of Sciences, 2016; 113 (15): E2189 DOI: 10.1073/pnas.1525096113


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