Short-Term Impact of Surgical Menopause on Cognitive Function in Women at Elevated Risk for Ovarian Cancer Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Wednesday, April 06, 2016

Short-Term Impact of Surgical Menopause on Cognitive Function in Women at Elevated Risk for Ovarian Cancer



study

 Summary
The purpose of this study is to identify changes in memory and cognition that may result from surgical menopause in women at high risk of ovarian cancer who choose to reduce their risk of cancer by having their tubes and ovaries removed. The study will examine whether hormone replacement therapy has an effect on memory and cognition.
Researchers will collect information about personal and family history of cancer, along with personal demographics, lifestyle habits and medical history. A cognitive assessment tool will be utilized to better understand individuals at high risk for ovarian cancer.

Study Coordinator and Contact

Inclusion Criteria

  • Planning to have surgery to remove both ovaries or remaining ovary if only one ovary is intact
  • No personal history of ovarian, peritoneal, or tubal cancer
  • Menstrual cycles in the past six months or is not yet menopausal
  • Currently has at least one ovary intact
  • High risk for ovarian cancer as defined by standard criteria to include:
  • Positive for breast cancer susceptibility gene (BRCA)
  • Positive for Lynch Syndrome
  • First degree relative with ovary cancer
  • Ashkenazi Jewish with a personal history of breast cancer
  • Two relatives with ovary cancer regardless of age of onset
  • Any relative diagnosed breast cancer with age of diagnosis less than 50
  • Family history of BRCA (patient not tested)
  • Family history of Lynch Syndrome (patient not tested)
  • At least 18 years old

Exclusion Criteria

  • Pregnant women
  • Children

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