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abstract
Objective:
Chemoresistance remains a major challenge in the treatment of ovarian
cancer. As part of a survival mechanism, tumor cells
have been shown to release proangiogenic
factors, such as vascular endothelial growth factor (VEGF), through a
mechanism that
involves the upregulation of hypoxia-induced
factor (HIF)-1α. The objective of this study was to compare the
expression of
VEGF and its receptors (R1 and R2) as well as
HIF-1α in chemoresistant epithelial ovarian cancer (EOC) cells to their
chemosensitive
counterparts and determine their impact on
angiogenesis.
Conclusion: Cisplatin-
and taxotere-resistant EOC cells are characterized by lower VEGF, VEGF
receptors, and HIF-1α, and decreased angiogenesis.
These findings may indicate a decrease in drug
delivery at the tumor site, hence allowing the persistence of
chemoresistant
EOC cells.
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