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abstract
Ultrasound in preoperative assessment of pelvis and abdominal spread in patients with ovarian cancer: a prospective study
Objective
To analyze the accuracy of ultrasound in assessing pelvic and intra-abdominal disease in patients with ovarian cancer.
Methods
This
prospective study enrolled all consecutive patients referred to a
single gynecologic oncology center for suspected ovarian cancer. Only
data with histologically confirmed primary ovarian cancer in patients
who were evaluated under predefined preoperative ultrasound,
intraoperative and pathologic protocols were analyzed. The rectosigmoid
wall infiltration depth, peritoneal involvement in different
compartments and metastatic lymph node presence were correlated with
histopathology.
Results
A
total of 578 patients were enrolled from 2008 to 2013; 394 patients met
the study criteria and their data were analysed, 74 % of them suffered
from advanced stage cancer. Our results showed excellent agreement
between ultrasound and histology in rectosigmoid wall infiltration
assessment (kappa value 0.812, AUC 0.898). The overall accuracy in
evaluating multiple abdominal peritoneal compartments and
retroperitoneal lymph nodes reached 85.3 % and 84.5 %, respectively. A
lower accuracy than 85 % was found in the assessment of diaphragm,
infracolic omentum, mesentery and retroperitoneal lymph nodes but
accuracy was at 90 % and higher for the evaluation of supracolic
omentum, abdominal wall and visceral peritoneum (liver, spleen, small
bowels, colon).
Conclusion
To
the best of our knowledge, this is the largest imaging study on ovarian
cancer staging done to date. In the study, ultrasound has shown high
accuracy in evaluating the rectosigmoid wall infiltration. In assessing
different peritoneal and retroperitoneal compartments, ultrasound was
accurate and highly specific. However, similar to other modern imaging
techniques, ultrasound revealed lower sensitivity, which further
supported the role of comprehensive surgical staging.
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