What made HIPEC an effective curative treatment for peritoneal surface malignancy: A 25-year experience with 1,125 procedures Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Tuesday, April 26, 2016

What made HIPEC an effective curative treatment for peritoneal surface malignancy: A 25-year experience with 1,125 procedures



What made hyperthermic intraperitoneal chemotherapy an effective curative treatment for peritoneal surface malignancy: A 25-year experience with 1,125 procedures 
 

Objective

To review our 25-year experience with hyperthermic intra-peritoneal chemotherapy (HIPEC).

Background

Combining cytoreductive surgery (CRS) and HIPEC as local treatments for peritoneal carcinomatosis (PC) was proposed 25 years ago.

Methods

A prospective database of all patients undergoing HIPEC for PC since 1989 was searched for clinicopathological data, 90-day morbidity and mortality, and survival.

Results

Among 1,125 HIPEC procedures, PC origin was colorectal (342; 30%), ovarian (271; 24%), pseudomyxoma peritonei (189; 17%), gastric (127; 11%), malignant mesothelioma (84; 8%), or other (112; 10%). Between 2004–2009 (n = 321) and 2010–2015 (n = 560), the median peritoneal cancer index decreased (11 vs. 8; P < 0.001), fewer patients underwent incomplete cytoreduction (CC2-3: 4% vs. 0.5%; P < 0.001), and more were included in randomized trials (5% vs. 16%; P < 0.001). Postoperative morbidity (52% vs. 50%, P = 0.672) was not different, but mortality significantly decreased (5% vs. 2%; P =  0.030). Median overall-survival was 42 months, and improved significantly for each 5-year period except for 2006–2010 vs. 2011–2015 (P =  0.097). The 10-year survival without recurrence was 53%, 14%, 4%, 10%, and 9% for pseudomyxoma, mesothelioma, ovarian, colorectal, and gastric PC, respectively.

Conclusion

This study demonstrated that CRS and HIPEC provide long-term survival irrespective of PC origin, and survival improves with experience. J. Surg. Oncol.

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