|
|
|
|
|
|
|
|
abstract
Consumption of whole grains and cereal fiber in relation to cancer risk: a systematic review of longitudinal studies
Published by Oxford University Press on behalf of the International Life Sciences Institute
Context:
Evidence from previous reviews is supportive of the hypothesis that
whole grains may protect against various cancers. However, the reviews
did not report risk estimates for both whole grains and cereal fiber and
only case–control studies were evaluated. It is unclear whether
longitudinal studies support this conclusion. Objective:
To evaluate associations between whole grains and cereal fiber in
relation to risk of lifestyle-related cancers data from longitudinal
studies was evaluated.
Data Sources: The following 3 databases were systematically searched: PubMed, EMBASE, and Cochrane CENTRAL.
Study Selection:
A total of 43 longitudinal studies conducted in Europe and North
America that reported multivariable-adjusted risk estimates for whole
grains (n = 14), cereal fiber (n = 23), or both (n = 6) in relation to
lifestyle-related cancers were included.
Data Extraction:
Information on study location, cohort name, follow-up duration, sample
characteristics, dietary assessment method, risk estimates, and
confounders was extracted.
Data Synthesis: Of 20
studies examining whole grains and cancer, 6 studies reported a
statistically significant 6%–47% reduction in risk, but 14 studies
showed no association. Of 29 studies examining cereal fiber intake in
relation to cancer, 8 showed a statistically significant 6%–49%
reduction in risk, whereas 21 studies reported no association.
Conclusions:
This systematic review concludes that most studies were suggestive of a
null association. Whole grains and cereal fiber may protect against
gastrointestinal cancers, but these findings require confirmation in
additional studies.
- cancer risk
- cereal fiber
- longitudinal studies
- systematic revi
0 comments :
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.