Helplessness/hopelessness, minimization and optimism predict survival in women with invasive ovarian cancer

abstract:
 Helplessness/hopelessness, minimization and optimism predict survival in women with invasive ovarian cancer: a role for targeted support during initial treatment decision-making?

AOCS—Quality of Life Study Investigators on behalf of the Australian Ovarian Cancer Study Group

PURPOSE:

Women with advanced ovarian cancer generally have a poor prognosis but there is significant variability in survival despite similar disease characteristics and treatment regimens. The aim of this study was to determine whether psychosocial factors predict survival in women with ovarian cancer, controlling for potential confounders.

METHODS:

The sample comprised 798 women with invasive ovarian cancer recruited into the Australian Ovarian Cancer Study and a subsequent quality of life study. Validated measures of depression, optimism, minimization, helplessness/hopelessness, and social support were completed 3-6 monthly for up to 2 years. Four hundred nineteen women (52.5 %) died over the follow-up period. Associations between time-varying psychosocial variables and survival were tested using adjusted Cox proportional hazard models.

RESULTS:

There was a significant interaction of psychosocial variables measured prior to first progression and overall survival, with higher optimism, higher minimization, and lower helplessness/hopelessness associated with longer survival. After disease progression, these variables were not associated with survival and helplessness/hopelessness. Depression and social support were not associated with survival.

CONCLUSIONS:

In women with invasive ovarian cancer, psychosocial variables prior to disease progression appear to impact on overall survival, suggesting a preventive rather than modifying role. Addressing psychosocial responses to cancer and their potential impact on treatment decision-making early in the disease trajectory may benefit survival and quality of life.