abstract
Is aspirin use associated with a decreased risk of ovarian cancer? A systematic review and meta-analysis of observational studies with dose-response analysis.
OBJECTIVE:
Currently available epidemiologic evidences concerning the chemopreventive effect of aspirin on
ovarian cancer
are inconsistent. Therefore, we aimed to further explore the
association by synthesizing evidence from population-based studies.
METHODS:
We
searched PubMed, EMBASE, Web of Science, and Scopus using key words and
controlled vocabularies. Title/abstract screening, full-text review,
data extraction, and quality assessment were performed independently by
reviewers, and a random-effects model was utilized for meta-analysis.
Subgroup analysis was conducted based on study locale, and sensitivity
analysis was performed by synthesizing studies that adjusted for certain
covariates or studies with good quality. Dose-response relation was
assessed by a two-stage linear dose-response model. Statistical
heterogeneity was evaluated by the I-squared value and a chi-squared
test for the Cochrane Q statistic.
RESULTS:
We
identified
8 cohort studies and 15 case-control studies......
CONCLUSION:
In summary, our study suggests that aspirin can reduce the risk of
ovarian cancer. In addition, we observed a possible dose-response relation between frequency of use and
ovarian cancer risk, but f
urther studies are needed to examine this association.
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