Lynch syndrome, Muir Torre variant: 2 cases (Peru) Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Sunday, May 08, 2016

Lynch syndrome, Muir Torre variant: 2 cases (Peru)



abstract

Lynch syndrome (LS) is an autosomal-dominant inherited cancer predisposition syndrome caused by germline mutations in DNA mismatch repair genes (MLH1, MSH2, MSH6 or PMS2). Muir-Torre syndrome (MTS) is a phenotypic variant of LS that includes a predisposition to sebaceous glands tumors and keratoacanthomas. We report two patients with MTS, with more than one LS-related cancer, skin lesions, family history of cancer and microsatellite instability and immunohistochemistry analysis.

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