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abstract
In a recent article, Wu et al. (Nature
2016;529:43-47) review previous studies and present new estimates for
the contribution
of extrinsic factors to cancer development. The new
estimates are generally close to 100%, even for bone and brain cancers
that have no known associations with lifestyle and
are typically not considered to be preventable. We find that the results
of Wu and colleagues are incompatible with previous
estimates derived from epidemiological and genetic data. We further
argue
that their methods are fundamentally flawed because
they overlook important effects of tissue type on cancer risk. We
therefore
conclude that their results give a misleading view
of cancer etiology and preventability.
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