Cumulative defects in DNA repair pathways drive the PARP inhibitor response in high-grade serous epithelial ovarian cancer cell lines Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

Blog Archives: Nov 2004 - present

#ovariancancers



Special items: Ovarian Cancer and Us blog best viewed in Firefox

Search This Blog

Monday, July 11, 2016

Cumulative defects in DNA repair pathways drive the PARP inhibitor response in high-grade serous epithelial ovarian cancer cell lines



open access

 Furthermore, our findings provide evidence that proficiency in NER or MMR may account for mechanisms of PARPi resistance, other than mutation reversal or p-glycoprotein up-regulation [55], to explain why BRCA mutated EOC patients do not respond favorably to Olaparib.
 

0 comments :

Post a Comment

Your comments?

Note: Only a member of this blog may post a comment.