Effects of lifestyle intervention in BRCA1/2 mutation carriers on nutrition, BMI, and physical fitness (LIBRE study)

(Germany) Effects of lifestyle intervention in BRCA1/2 mutation carriers on nutrition, BMI, and physical fitness (LIBRE study): study protocol for a randomized controlled trial | Trials | Full Text

 Discussion

As data on the role of lifestyle intervention in women with a hereditary risk for breast and ovarian cancer are currently lacking, this study will be of major importance from a scientific, as well as a practical advice viewpoint. It will investigate the optimal strategy to improve physical fitness, nutritional status, and psychological factors such as quality of life, perceived stress, optimism, as well as incidence and outcome of cancer in this selected group of women at high risk. If the study indicates a positive long-term outcome, a structured lifestyle intervention program could be added to health care prevention strategies for BRCA1 and BRCA2 mutation carriers.

Trial registration

ClinicalTrials.gov: NCT02516540. Registered on 22 July 2015.

 

Locations

Germany
Humboldt Universität zu Berlin	Recruiting
Berlin, Germany
Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden	Recruiting
Dresden, Germany
Universitätsklinikum Düsseldorf	Recruiting
Düsseldorf, Germany
Kliniken Essen-Mitte	Recruiting
Essen, Germany
Universitätsklinikum Essen	Not yet recruiting
Essen, Germany
Universitätsklinikum Freiburg	Not yet recruiting
Freiburg, Germany
Universitätsmedizin Göttingen	Not yet recruiting
Göttingen, Germany
Medizinische Hochschule Hannover	Recruiting
Hannover, Germany
Universitätsklinium Heidelberg	Recruiting
Heidelberg, Germany
Universitätsklinikum Schleswig-Holstein, Campus Kiel	Recruiting
Kiel, Germany
Uniklinikum Köln	Not yet recruiting
Köln, Germany
Universitätsklinikum Leipzig	Not yet recruiting
Leipzig, Germany
Technische Universität München	Recruiting
München, Germany
Universität Regensburg	Not yet recruiting
Regensburg, Germany
Universitätsklinikum Tübingen	Recruiting
Tübingen, Germany
Universität Ulm	Not yet recruiting
Ulm, Germany
Universitätsklinikum Würzburg	Not yet recruiting
Würzburg, Germany

Sponsors and Collaborators

Technische Universität München

University of Hohenheim

University of Schleswig-Holstein

University of Leipzig

University of Cologne