Low-Grade Serous Carcinoma of the Ovary (Cancer Network) Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Saturday, July 16, 2016

Low-Grade Serous Carcinoma of the Ovary (Cancer Network)



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 Introduction

The World Health Organization classification system of ovarian cancer, published in 2014 by Kurman et al, eliminated the older practice of grading serous tumors on a continuum (grade 1, 2, or 3) and instead differentiates low-grade serous and high-grade serous ovarian cancers as two distinct diseases.[1] In general, tumors previously classified as grade 1, and most of those classified as grade 2 according to the old system, are now classified as low-grade serous ovarian cancers (LGSOCs). Those tumors previously classified as grade 3 are now considered high-grade serous ovarian cancers (HGSOCs)....

 KEY POINTS
  • Low-grade serous ovarian cancer is a rare disease, accounting for < 10% of ovarian cancer cases.
  • Initial treatment consists of surgical staging and adjuvant chemotherapy.
  • Recurrent disease is relatively chemoresistant;
    hormonal therapies, as well as bevacizumab and MEK inhibitors, have shown some promising results.

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