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Tuesday, August 23, 2016

Challenging Roadblocks to Cancer Cure





open access - pdf

Abstract

The Pezcoller Symposium in Trento, Italy, June 2015, focused entirely on the question of why advanced cancer cure is so uncommon despite the extraordinarily rapid growth of invaluable therapeutic information. Participants were asked to define and to critically evaluate real and potential obstacles to permanent disease eradication. High-level concepts on potential road blocks to cures as well as opportunities for intervention in diverse areas of investigation ranging from genomic alterations to metabolism, microenvironment, immunity, and mechanotransduction were discussed. Provocative concepts and novel therapeutic avenues were proposed. What follows is a critical analysis of the highlights of this meeting.  
Cancer Res; 76(17); 1–7. ©2016 AACR.

Finally, knowing in detail what molecular capabilities manifested
by a patient's tumor have the potential to promote future
clinical lethality may, when suitably impeded, prove important to
converting remissions or stable disease into long-term survival.

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