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open access - pdf
Abstract
The
Pezcoller Symposium in Trento, Italy, June 2015, focused entirely on
the question of why advanced cancer cure is so uncommon despite the
extraordinarily rapid growth of invaluable therapeutic information.
Participants were asked to define and to critically evaluate real and
potential obstacles to permanent disease eradication. High-level
concepts on potential road blocks to cures as well as opportunities for
intervention in diverse areas of investigation ranging from genomic
alterations to metabolism, microenvironment, immunity, and
mechanotransduction were discussed. Provocative concepts and novel
therapeutic avenues were proposed. What follows is a critical analysis
of the highlights of this meeting.
Cancer Res; 76(17); 1–7. ©2016 AACR.
Finally, knowing in detail what molecular capabilities manifested
by a patient's tumor have the potential to promote future
clinical lethality may, when suitably impeded, prove important to
converting remissions or stable disease into long-term survival.
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