Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations | Cancer Research Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Tuesday, August 23, 2016

Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations | Cancer Research



 Definition of Pleiotropic - MedicineNet
Pleiotropic: Producing or having multiple effects from a single gene.
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abstract
Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations
AACR
 on behalf of Ovarian Cancer Association Consortium (OCAC), on behalf of The PRACTICAL Consortium, on behalf of Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), on behalf of Colorectal Transdisciplinary (CORECT) Study, on behalf of African American Breast Cancer Consortium (AABC) and African Ancestry Prostate Cancer Consortium (AAPC)

 Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression.

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