Cutaneous Metastases of the Synchronous Primary Endometrial & Bilateral Ovarian Cancer (Case Report/Review)

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Cutaneous Metastases of the Synchronous Primary Endometrial and Bilateral Ovarian Cancer: An Infrequent Presentation and Literature Review

 In this paper, we report a 51-year-old woman with FIGO Stage 1A Grade 1 endometrial endometrioid-type adenocarcinoma and synchronous FIGO Stage 1B bilateral ovarian endometrioid-type adenocarcinoma who presented 34 months following total abdominal hysterectomy and bilateral salpingo-oophorectomy with skin metastases. Similar cases in the literature are reviewed.

 3. Discussion

Cutaneous (skin) metastasis is a relatively uncommon manifestation of internal malignancies. It most often occurs late in the course of disease but may also be the first presentation of underlying cancers. The overall incidence of cutaneous metastases from visceral neoplasm is 5.3%, ranging from 0.7% to 10% [1, 3]. The tumor with the highest incidence of cutaneous metastases is breast cancer. Lung cancer, colorectal cancer, renal cancer, ovarian cancer, and bladder cancer all have similar rates for cutaneous metastases between 3.4% and 4% [3]. In the tumors arising from female genital tract, the prevalence of metastases to skin has been cited as 0.7%–1.3% in cervical carcinoma [5], 0.8% in endometrial carcinoma [6], and 1.9% to 5.1% in ovarian carcinoma [7]. In the literature, we did not find such a study that reported cutaneous metastases from the endometrioid-type endometrial adenocarcinoma of uterine corpus and synchronous bilateral ovarian endometrioid-type adenocarcinoma.....