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Patient Preferences: More Complex Than Maximizing Survival Time
August 11, 2016
Discrepancies Among Patient-oriented Variables
As new PRO (Patient Reported Outcomes) endpoints become more widely employed in research, even in
the measurement of quality of care in clinical settings, it is
important to clearly distinguish PROs from patient preferences and
quality of life, emphasized Richard Schilsky, MD, FASCO, FACP, chief
medical officer of the American Society of Clinical Oncology (ASCO) in
Alexandria, Virginia.
“They're not all the same thing,” Dr Schilsky cautioned. “Patient
preferences are typically just that: I prefer to receive this treatment
every week than that 1 every 3 weeks. That's a patient preference.
Treatments may produce similar outcomes except that 1 is associated with
neuropathy—nerve damage—and another is associated more commonly with
diarrhea. If I'm a professional violinist, my preference is to avoid
nerve damage at all costs, because that will affect my career.”
PROs, in contrast, are measurements of a patient's own experience,
usually regarding adverse events associated with treatment, such as
pain, nausea, or fatigue, Dr Schilsky said. “Quality of life is
typically a more global assessment of how a patient is going through her
life experiences. It has many domains, many scales—such as social
support, physical functioning, psychological—and they all roll up into
an overall ‘Quality of Life' assessment.”......
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