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Monday, August 15, 2016

Publication status of contemporary oncology randomised controlled trials worldwide



abstract
 

Conclusions

Despite the ethical obligations and societal expectations of disclosing findings promptly, oncology RCTs performed poorly.

Highlights

Little is known about the publication status of contemporary oncology RCTs worldwide.
We found one-third of the trials remained unpublished after at least 3 years of completion.
More than two-thirds of the trials were unpublished timely within 24 months of completion.
Trials conducted in Asia and other regions were less likely to be published timely.
There was a trend for timely publication of positive trials compared with negative ones.

 We identified 598 completed oncology RCTs; overall, 398 (66.6%) had been published. For published trials, the median time to publication was 25 months (interquartile range, 16–37 months). Only 192 trials (32.1%) were published within 24 months. Timely publication was independently associated with trials completed late in 2012.
 

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