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Wednesday, August 10, 2016

recent (sundry) items: google scholar search "ovarian cancer"

Scholar Alert: [ intitle:"ovarian cancer" ]; Articles excluding patents

Socioeconomic Status in Relation to the Risk of Ovarian Cancer in African-American Women: A Population-Based Case-Control Study

AJ Alberg, PG Moorman, S Crankshaw, F Wang… - American Journal of …, 2016
Abstract We investigated the association between socioeconomic status and ovarian cancer
in African-American women. We used a population-based case-control study design that
included case patients with incident ovarian cancer (n= 513) and age-and area-matched ...

Clinical relevance of kallikrein-related peptidase 6 (KLK6) and 8 (KLK8) mRNA expression in advanced serous ovarian cancer.

N Ahmed, J Dorn, R Napieralski, E Drecoll, M Kotzsch… - Biological chemistry, 2016
Most members of the kallikrein-related peptidase family have been demonstrated to be
dysregulated in ovarian cancer and modulate tumor growth, migration, invasion, and
resistance to chemotherapy. In the present study, we assessed the mRNA expression ...

European Society of Gynaecologic Oncology Quality Indicators for Advanced Ovarian Cancer Surgery.

D Querleu, F Planchamp, L Chiva, C Fotopoulou… - International Journal of …, 2016
Objectives: The surgical management of advanced ovarian cancer involves complex
surgery. Implementation of a quality management program has a major impact on survival.
The goal of this work was to develop a list of quality indicators (QIs) for advanced ovarian ...

CXCL9 and CXCL10 predict survival and are regulated by cyclooxygenase inhibition in advanced serous ovarian cancer

H Bronger, J Singer, C Windmüller, U Reuning, D Zech… - British Journal of Cancer, 2016
Background: Tumour-infiltrating lymphocytes (TILs) are associated with improved survival in
several epithelial cancers. The two chemokines CXCL9 and CXCL10 facilitate chemotactic
recruitment of TILs, and their intratumoral accumulation is a conceivable way to improve ...

[PDF] Association of Immunosuppression with DR6 Expression during the Development and Progression of Spontaneous Ovarian Cancer in Laying Hen Model

SR McNeal, P Bitterman, JM Bahr, SL Edassery… - Journal of Immunology …, 2016
Ovarian cancer (OVCA) mainly disseminates in the peritoneal cavity. Immune functions are
important to prevent OVCA progression and recurrence. The mechanism of
immunosuppression, a hallmark of tumor progression, is not well understood. The goal of ...

Hypoxia-NOTCH1-SOX2 signaling is important for maintaining cancer stem cells in ovarian cancer.

EJ Seo, DK Kim, IH Jang, EJ Choi, SH Shin, SI Lee… - Oncotarget, 2016
Hypoxia and NOTCH signaling have been reported to be associated with the self-renewal
and drug resistance of cancer stem cells (CSCs). However, the molecular mechanisms by
which hypoxia and NOTCH signaling stimulate the self-renewal and drug resistance of ...

The status of poly (adenosine diphosphate-ribose) polymerase (PARP) inhibitors in ovarian cancer, part 1: olaparib.

RE Miller, JA Ledermann - Clinical advances in hematology & oncology: H&O, 2016
Poly (adenosine diphosphate-ribose) polymerase (PARP) inhibitors have shown promising
clinical activity in epithelial ovarian cancer. Following the observation in vitro that PARP
inhibition is synthetically lethal in tumors with BRCA mutations, PARP inhibition has ...

Depletion of Dicer promotes epithelial ovarian cancer progression by elevating PDIA3 expression

Y Zhu, L Cai, J Guo, N Chen, X Yi, Y Zhao, J Cai… - Tumor Biology, 2016
Abstract Dicer is an essential component of the microRNA (miRNA) processing machinery
whose low expression is associated with advanced stage and poor clinical outcome in
epithelial ovarian cancer. To investigate the functional relevance of Dicer in epithelial ...

Use of PlasmaJet for Peritoneal Carcinomatosis in Ovarian Cancer.

E Panuccio, K Leunen, E Van Nieuwenhuysen… - International journal of …, 2016
OBJECTIVE: This study aimed to assess the role and complications of extensive
cytoreduction with PlasmaJet (Plasma Surgical, Roswell, Ga) in ovarian cancer with
peritoneal carcinomatosis. MATERIALS: All patients undergoing primary, secondary, or ...

Exendin-4 inhibits growth and augments apoptosis of ovarian cancer cells

W He, S Yu, L Wang, M He, X Cao, Y Li, H Xiao - Molecular and Cellular …, 2016
Abstract Glucagon-like peptide (GLP)-1 promotes proliferation and survival in β-cell;
however, whether GLP-1 receptor agonists promote growth of human ovarian cancer cells
remain unknown. We aimed to explore the effects of GLP-1 agents on ovarian cancer cells ...

Therapeutic targets and new directions for antibodies developed for ovarian cancer

HJ Bax, DH Josephs, G Pellizzari, JF Spicer, A Montes… - mAbs, 2016
Abstract Antibody therapeutics against different target antigens are widely used in the
treatment of different malignancies including ovarian carcinomas, but this disease still
requires more effective agents. Improved understanding of the biological features, ...

Current South African clinical Practice in Debulking Surgery for Ovarian Cancer.

J Billson, FH van der Merwe, RP Soeters - … of gynecological cancer: official journal of …, 2016
INTRODUCTION: The aim of this study was to assess practice patterns and rationale with
regard to debulking surgery for advanced epithelial ovarian carcinoma among South African
Gynaecological oncologists. METHODS: A survey was distributed to all practicing ...

The Emerging Role of Tyrosine Kinase Inhibitors in Ovarian Cancer Treatment: A Systematic Review

I Ntanasis-Stathopoulos, G Fotopoulos, IG Tzanninis… - Cancer Investigation, 2016
ABSTRACT The present systematic review summarizes current evidence regarding the
mechanisms of action, the efficacy, and the adverse effects of tyrosine kinase inhibitors
(TKIs) in ovarian cancer patients. Phase II and III clinical trials were sought in the PubMed ...

Bayesian analysis for mixture nonlinear mixed-effects models with skewed random effects and errors with application to an ovarian cancer study

CC Chen - 2016
Abstract It is common to analyze longitudinal data using nonlinear mixed-effects (NLME)
model. And we often use NLME model with normality and homogeneity assumption.
However, this assumption may be unrealistic in practice. Our aim is to model the longitu-

[HTML] Locomotor proteins in tissues of primary tumors and metastases of ovarian and breast cancer

IV Kondakova, NV Yunusova, LV Spirina, EE Shashova… - PHYSICS OF CANCER: …, 2016
... and metastases of ovarian and breast cancer. Contents of p45 Ser β-catenin and
the actin severing protein gelsolin were decreased in metastases of ovarian cancer
relative to primary tumors. The level of the cofilin, functionally ...

[PDF] Investigating the Role of Extracellular Matrix Proteins in Ovarian Folliculogenesis and Ovarian Cancer

A Carrier - 2016
Abstract The extracellular matrix (ECM) is a highly organized, dynamic structure that
maintains tissue integrity and regulates biological processes involved in organ development
and function. To explore the role of ECM proteins in ovarian physiology and pathology, my ...

[PDF] Transcription in Ovarian Cancer Cell Lines

HW von König, M Breidenbach, MM Valter…
Abstract The clinical observation of the multidrug resistance (MDR) phenotype is often
associated with overexpression of the mdr1 gene, in particular with respect to ovarian
cancer. However, until now the mdrl-inducing potential of commonly used antineoplastics ...

Prevalence and distribution pattern of nodal metastases in advanced ovarian cancer

C Bachmann, R Bachmann, B Kraemer, SY Brucker… - Molecular and Clinical Oncology
Abstract The objective of this study was to examine the relevance of pelvic and para‑aortic
lymph node involvement and the tumour characteristics affecting nodal metastases and
survival in primary advanced ovarian cancer. A total of 130 consecutive patients were ...

[PDF] Microfluidics and spectroscopic imaging for personalized medicine in ovarian cancer

AM Mes-Masson, T Gervais
With certain cancers, such as ovarian cancers, a significant number of patients are non-
responsive to the standard chemotherapy treatment. These patients, therefore, experience
the negative side effects of chemotherapy without clinical benefits. With the everincreasing ...

Characterization of BRCA1 and BRCA2 variants found in a Norwegian breast or ovarian cancer cohort

E Jarhelle, HMFR Stensland, L Mæhle, M Van Ghelue - Familial Cancer
Abstract Germline mutations in BRCA1 and BRCA2 cause hereditary breast and ovarian
cancer. Molecular screening of these two genes in patients with a family history of breast or
ovarian cancer has revealed pathogenic variants as well as genetic variants of unknown ...


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