Refining Ovarian Cancer Test accuracy Scores (ROCkeTS): protocol for a prospective longitudinal test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Wednesday, August 10, 2016

Refining Ovarian Cancer Test accuracy Scores (ROCkeTS): protocol for a prospective longitudinal test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer



open access:
Refining Ovarian Cancer Test accuracy Scores (ROCkeTS): protocol for a prospective longitudinal test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer
  
 The study will recruit 2450 patients from 15 UK sites.
Methods and analysis ROCkeTS comprises four parallel phases. The full ROCkeTS protocol can be found at http://www.birmingham.ac.uk/ROCKETS. Phase III is a prospective test accuracy study.

ROCkeTS study design

Aim of the study

  • To derive and validate risk prediction models that estimate the probability of having OC for women with symptoms suggestive of OC for postmenopausal and premenopausal women.
  • To identify optimal risk thresholds of best models for the diagnosis of OC that can guide patient management.

    Design

    The ROCkeTS study is a single-arm prospective cohort diagnostic test accuracy study to evaluate existing and novel risk prediction models for premenopausal and postmenopausal women with symptoms.

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