Risk estimates for Lynch syndrome (interactive chart) - with/without prior cancer

Prospective Lynch Syndrome Database

• Carrier without previous cancer 
• Carrier with previous cancer 
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Recent news

[ Dec-08-2015 ]     LScarisk.org launched
[ Jun-03-2016 ]     Risk estimates for subsequent cancers have been added

 About LScarisk.org
This website is based on the following publications:

Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database. Gut. 2015 Dec 9.
Møller P, Seppälä T, Bernstein I, Holinski-Feder E, Sala P, Evans DG, Lindblom A, Macrae F, Blanco I, Sijmons R, Jeffries J, Vasen H, Burn J, Nakken S, Hovig E, Rødland EA, Tharmaratnam K, de Vos Tot Nederveen Cappel WH, Hill J, Wijnen J, Jenkins M, Green K, Lalloo F, Sunde L, Mints M, Bertario L, Pineda M, Navarro M, Morak M, Renkonen-Sinisalo L, Frayling IM, Plazzer JP, Pylvanainen K, Genuardi M, Mecklin JP, Möslein G, Sampson JR, Capella G; Mallorca Group (http://mallorca-group.org).(2016)

Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database. Gut. 2016 Jun 3
Note that the number of PMS2 carriers included are insufficient for realiable conclusions. Risk estimates for PMS2 carriers should therefore be interpreted with caution.
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Editors: Sigve Nakken, Eivind Hovig, & Pål Møller