Correspondence: Flawed external validation study of the ADNEX model to diagnose ovarian cancer Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Tuesday, September 20, 2016

Correspondence: Flawed external validation study of the ADNEX model to diagnose ovarian cancer



open access

14 September 2016
 
Dear Editor,
 
External validation studies of prediction models are of utmost importance in order to assess the performance of a prediction model in different locations (Altman et al., 2009). We therefore read with interest the recent external validation study of the ADNEX model (Szubert et al., 2016)......


    • S. Szubert, A. Wojtowicz, R. Moszynski, P. Zywica, K. Dyczkowski, A. Stachowiak, et al.
    • External validation of the IOTA ADNEX model performed by two independent gynecologic centers
    • Gynecol. Oncol. (2016)
    • Highlights (abstract)

       

      We performed external validation of IOTA ADNEX model in two European centers.
      The study confirms high discrimination accuracy of the ADNEX model.
      The prediction of specific tumor type had moderate performance.
      The results were comparable to original IOTA report and similar between two centers.

References

    • Moons et al., 2015
    • K.G. Moons, D.G. Altman, J.B. Reitsma, J.P. Ioannidis, P. Macaskill, E.W. Steyerberg, et al.
    • Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD): explanation and elaboration
    • Ann. Intern. Med., 162 (2015), pp. W1–73
    • Riley et al., 2016
    • R.D. Riley, J. Ensor, K.I. Snell, T.P. Debray, D.G. Altman, K.G. Moons, et al.
    • External validation of clinical prediction models using big datasets from e-health records or IPD meta-analysis: opportunities and challenges
    • BMJ, 353 (2016), p. i3140
    • Steyerberg, 2009
    • E.W. Steyerberg
    • Clinical Prediction Models. A Practical Approach to Development, Validation, and Updating
    • Springer-Verlag, New York (2009)

    • Szubert et al., 2016
    • S. Szubert, A. Wojtowicz, R. Moszynski, P. Zywica, K. Dyczkowski, A. Stachowiak, et al.
    • External validation of the IOTA ADNEX model performed by two independent gynecologic centers
    • Gynecol. Oncol. (2016)

    • Van Calster et al., 2014
    • B. Van Calster, K. Van Hoorde, L. Valentin, A.C. Testa, D. Fischerova, C. Van Holsbeke, et al.
    • Evaluating the risk of ovarian cancer before surgery using the ADNEX model to differentiate between benign, borderline, early and advanced stage invasive, and secondary metastatic tumours: prospective multicentre diagnostic study
    • BMJ, 349 (2014), p. g5920

Corresponding author at: KU Leuven, Department of Development and Regeneration, Leuven, Belgium.
1
STRATOS initiative (STRengthening Analytical Thinking for Observational Studies), Topic Group 6 on evaluating diagnostic tests and prediction models.

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