“Genetic Predisposition in Gynecologic Cancers” (Lynch & ovarian??) paywalled Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Wednesday, September 21, 2016

“Genetic Predisposition in Gynecologic Cancers” (Lynch & ovarian??) paywalled

abstract - Seminars in Oncology

Dept. of Gynecologic Oncology and Reproductive Medicine, MD Anderson Cancer Center, 1155 Pressler, Unit 1362, Houston, TX 77030

 This review article discusses the diagnosis and management of hereditary ovarian cancer and hereditary uterine cancer. The key recommendations highlighted are: All women with high grade non-mucinous epithelial ovarian cancer should be offered at least BRCA1 and BRCA2 genetic testing. The care of women with BRCA-associated ovarian cancer should be tailored to their mutation status. Risk reducing bilateral salpingo-oophorectomy is recommended for women with BRCA1/2 mutations. Women with endometrial cancer should be assessed for the possibility of Lynch syndrome. Individuals with Lynch syndrome should undergo screening colonoscopy every 1-2 years. Lynch syndrome causes a high risk of endometrial cancer, and women with Lynch syndrome should consult with a gynecologic specialist to formulate a plan for managing this risk.


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