abstract
2016 Aug 31
PURPOSE OF REVIEW:
Upper
tract urothelial carcinoma (UTUC) is a relatively rare and poorly
investigated disease. The objective of this review was to discuss recent
advances in genomics and their implication regarding prognosis and
treatment.
RECENT FINDINGS:
UTUC
were compared with urothelial carcinoma of the bladder (UCB) at genomic
and transcriptomic levels. Molecular studies focused on identifying new
prognostic biomarkers that were often initially described in UCB and
extrapolated to UTUC. Some of them could be interesting to improve the
management of UTUC.
SUMMARY:
Recent
studies improved our understanding of UTUC as a distinct entity
compared with UCB. Although UTUC shares many of the same genomic
alterations with UCB, some key differences have been identified as
oncogenic drivers of these cancers. This better comprehension of
genomics could lead to new prognostic markers that may refine UTUC
treatment.
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