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abstract
Background Over the
last two decades, ovarian cancer mortality rates have levelled or
declined. There are, however, persisting and substantial
differences in ovarian cancer patterns and
trends.
Patients and methods We updated global trends in ovarian cancer mortality to 2012, and predicted trends in rates to 2020 using data from the World
Health Organization database.
Results In the EU,
age-adjusted ovarian cancer mortality rates decreased 10% between 2002
and 2012, to 5.2/100 000. The decline was
∼16% in the USA, to 4.9/100 000 in 2012. Latin
American countries had lower rates, and declines were observed in
Argentina
and Chile. Likewise, modest declines (−2.1%)
were observed in Japan, whose rate remained low (3.2/100 000 in 2012).
Australia
had a rate of 4.3/100 000 in 2012, and a 12%
decline. The falls were larger in young women, than in middle or old
age. Recent
rates at age 20–49 were higher in Japan than in
the EU and the USA. Predictions to 2020 indicate a further 15% decline
in
the USA and 10% in the EU and Japan.
Conclusions The main
reason for the favourable trends is the use of oral contraceptives
(OCs), particularly, in the USA and countries
of the EU where OCs were introduced earlier.
Declines in menopausal hormone use may also have played a favourable
role in
elderly women, as well as improved diagnosis,
management and treatment.
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