Serous tubal intraepithelial carcinoma (STIC)
abstract
Highlights
- •In this cohort, 5.4% of asymptomatic BRCA mutation carriers had occult carcinomas in risk-reducing surgery specimens.
- •Patients with STIC had a higher incidence of subsequent serous cancer than those with benign adnexa.
- •The optimal postoperative management of patients with occult STIC lesions is unknown.
Objective
To
report the frequency and features of occult carcinomas and the
incidence of subsequent cancers following risk-reducing
salpingo-oophorectomy (RRSO) in BRCA mutation carriers.
Methods
257 consecutive women with germline BRCA
mutations who underwent RRSO between January 1, 2000 and December 31,
2014 were identified in an Institutional Review Board approved study.
All patients were asymptomatic with normal physical exams, CA 125
values, and imaging studies preoperatively, and had at least 12 months
of follow-up post-RRSO. All patients had comprehensive adnexal
sectioning performed. Patient demographics and clinico-pathologic
characteristics were extracted from medical and pathology records.
Results
The cohort included 148 BRCA1, 98 BRCA2, 6 BRCA not otherwise specified (NOS), and 5 BRCA1 and 2
mutation carriers. Occult carcinoma was seen in 14/257 (5.4%) of
patients: 9 serous tubal intraepithelial carcinomas (STIC), 3 tubal
cancers, 1 ovarian cancer, and 1 endometrial cancer. Three patients
(1.2%) with negative pathology at RRSO subsequently developed primary
peritoneal serous carcinoma (PPSC), and 2 of 9 patients (22%) with STIC
subsequently developed pelvic serous carcinoma. 110 women (43%) were
diagnosed with breast cancer prior to RRSO, and 14 of the remaining 147
(9.5%) developed breast cancer following RRSO. Median follow-up of the
cohort was 63 months.
Conclusion
In this cohort, 5.4% of asymptomatic BRCA
mutation carriers had occult carcinomas at RRSO, 86% of which were
tubal in origin. The risk of subsequent PPSC for women with benign
adnexa at RRSO is low; however, the risk of pelvic serous carcinoma
among women with STIC is significantly higher.
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