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Wednesday, September 14, 2016

Sleep Duration and Cancer in the NIH-AARP Diet and Health Study Cohort



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Background

Very few studies have examined sleep duration in relation to cancer incidence with the exception of breast cancer.

Methods

We assessed the associations between sleep duration and incidences of total and 18 site-specific cancers in the NIH-AARP Health and Diet Study cohort, with 173,327 men and 123,858 women aged 51–72 years at baseline. Self-reported sleep duration categories were assessed via questionnaire. We used multivariable Cox proportional hazards regression to estimate hazard ratios (HR) and 95% confidence intervals (CI), using 7–8 hours/night as the reference.

 A decreased ovarian cancer risk ≥ 9 vs. 7–8 hours

Study population

The NIH-AARP Diet and Health Study, described in detail previously [23], was established in 1995–1996 to evaluate association of diet and health. A total of 567,169 of 3.5 million members of AARP (formerly known as the American Association of Retired Persons), aged 50–71, completed baseline questionnaires, who resided in one of six states (California, Florida, Pennsylvania, New Jersey, North Carolina, and Louisiana) or in two metropolitan areas (Atlanta, Georgia and Detroit, Michigan).....

 Incident cancer cases were invasive and consisted only of the first malignant neoplasm diagnosed during the follow-up period if multiple cancers had been diagnosed in the same participant....
 Sensitivity analyses by removing physical activity, sedentary behavior, BMI, diabetes, hypertension, or any dietary variables did not change our results and conclusion (S1 Table). Removing cancers diagnosed within the first two years of follow-up did not change our observation materially (S2 Table).

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