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Background
Very few studies have examined sleep duration in relation to cancer incidence with the exception of breast cancer.
Methods
We
assessed the associations between sleep duration and incidences of
total and 18 site-specific cancers in the NIH-AARP Health and Diet Study
cohort, with 173,327 men and 123,858 women aged 51–72 years at
baseline. Self-reported sleep duration categories were assessed via
questionnaire. We used multivariable Cox proportional hazards regression
to estimate hazard ratios (HR) and 95% confidence intervals (CI), using
7–8 hours/night as the reference.
A decreased ovarian cancer risk ≥ 9 vs. 7–8 hours
Study population
The NIH-AARP Diet and Health Study, described in detail previously [23],
was established in 1995–1996 to evaluate association of diet and
health. A total of 567,169 of 3.5 million members of AARP (formerly
known as the American Association of Retired Persons), aged 50–71,
completed baseline questionnaires, who resided in one of six states
(California, Florida, Pennsylvania, New Jersey, North Carolina, and
Louisiana) or in two metropolitan areas (Atlanta, Georgia and Detroit,
Michigan).....
Incident cancer cases were invasive and consisted only of the first
malignant neoplasm diagnosed during the follow-up period if multiple
cancers had been diagnosed in the same participant....
Sensitivity analyses by removing physical activity, sedentary behavior,
BMI, diabetes, hypertension, or any dietary variables did not change our
results and conclusion (S1 Table). Removing cancers diagnosed within the first two years of follow-up did not change our observation materially (S2 Table).
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