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abstract:
The Impact of an Expanded Genetic Testing Program and Selective Oophorectomy on the Incidence of Ovarian Cancer in West Pomerania
The
aim of the study was to evaluate the impact of a regional
population-based genetic testing program on the incidence of ovarian
cancer in West Pomerania. Between 1999 and 2010, a total of 37,552 women
ages 35 to 70 were tested for three BRCA1 founder mutations at the
outpatient genetics clinic of the Pomeranian Medical University in
Szczecin, Poland. 641 women were found to carry a mutation (1.7%) and of
these, 220 had a prophylactic oophorectomy (34.3%).
12
women had an occult cancer diagnosed at the time of prophylactic
oophorectomy (5.5%). We estimate that 26 more ovarian cancers would have
been diagnosed by January 2015 in the absence of these oophorectomies
and that an additional 25 cancers will be prevented in the future (total
51). During this period, 1,611 ovarian cancers were diagnosed in the
region; therefore we estimate that approximately 1.6% of ovarian cancers
were prevented between 1999 and 2015 by our genetic testing program. We
conclude that the prophylactic oophorectomies performed between 1999
and 2010 as a result of widespread BRCA1 mutation testing have reduced
the incidence of ovarian cancer in Pomerania by a small amount (about
1.6%), and that the impact of genetic testing will increase in the
coming years.
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