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Diuresis is when the body has too many of certain substances in the fluid that the kidneys filter. Eventually this fluid becomes urine and increases the amount of water expelled by the body, leading to increased or excessive urination.
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abstract:
Highlights
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- Positive fluid status is common after cytoreductive surgery for advanced epithelial ovarian cancer.
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- Positive fluid status after cytoreductive surgery is associated with surgical site infections.
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- Fluid management is a key component of interventions to prevent surgical site infections.
Objective
The
objective of this study is to investigate the impact of fluid status on
perioperative outcomes of patients undergoing cytoreductive surgery
(CRS) for advanced epithelial ovarian cancer (EOC).
Methods
Patients
undergoing CRS for stage III or IV EOC at a comprehensive cancer center
from 12/2010 to 05/2015 were identified. Those who underwent upper
abdominal procedures or colon resections were included. Demographic,
perioperative, and 30-day complication data were collected.
Perioperative weight change was utilized as a surrogate for fluid
status. The time to diuresis (tD) was defined as the postoperative day
the patient's weight began to downtrend.
Results
One hundred ten patients were included. Median age was 62 years and median BMI 25.8 kg/m2.
The majority (74.5%) were stage IIIC. At least 1 bowel resection was
performed in 60 cases (54.5%). A median of 5381 mL of crystalloid (range
1000–17,550 mL) and 500 mL of colloids (range 0–2783 mL) was given
intraoperatively. The median perioperative weight change was + 7.3 kg
(range − 0.9 kg to + 35.7 kg). The median tD was 3 days (range
1–17 days). On univariate analysis, net positive fluid status was
associated with unscheduled reoperation, anastomotic leak, surgical site
infections (SSI), and length of stay > 5 days. On multivariate
analysis, fluid status was independently associated with SSI (p = 0.01). (surgical site infection)
Conclusions
Perioperative fluid excess is common in patients undergoing CRS for EOC and is independently associated with SSI.
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