abstract:
Prognostic value of endometriosis in patients with stage I ovarian clear cell carcinoma: Experiences at three academic institutions
Highlights
- •OCCC patients with EAOC had significantly improved survival than those without EAOC.
- •EAOC was not an independent prognostic predictor for patients with stage I OCCC.
- •The intrinsic relationship between EAOC and OCCC warrants further investigation.
Objectives
To investigate the prognostic value of endometriosis in patients with stage I ovarian clear cell carcinoma (OCCC).
Methods
The
medical records of patients with stage I OCCC who had undergone
complete staging surgery followed by systemic chemotherapy were
retrospectively reviewed.
Results
A
total of 237 women were included in this study. Univariate analysis
revealed that the patients with endometriosis-associated ovarian
carcinoma (EAOC) had significantly improved recurrence-free survival
(RFS) and overall survival (OS) than those without EAOC (5-year RFS:
91.4% vs. 73.0%, respectively, and 5-year OS: 97.5% vs. 89.9%). However,
EAOC was not identified as a significant prognostic predictor in
multivariate analysis. The potential risk factors determined to be
associated with EAOC included the pretreatment CA-125 level, FIGO stage,
lymphovascular space invasion (LVSI), and menopausal status (P < 0.001, P = 0.0031, P = 0.020, and P = 0.038, respectively).
Conclusions
Endometriosis
was not independently associated with the prognosis of the OCCC
patients, even when the tumor was confined to stage I. However, the
intrinsic relationship between endometriosis and OCCC warrants further
investigation.
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