Prognostic value of endometriosis in patients with stage I ovarian clear cell carcinoma: Experiences at 3 academic institutions Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Tuesday, October 18, 2016

Prognostic value of endometriosis in patients with stage I ovarian clear cell carcinoma: Experiences at 3 academic institutions



abstract:
Prognostic value of endometriosis in patients with stage I ovarian clear cell carcinoma: Experiences at three academic institutions

Highlights

  • OCCC patients with EAOC had significantly improved survival than those without EAOC.
  • EAOC was not an independent prognostic predictor for patients with stage I OCCC.
  • The intrinsic relationship between EAOC and OCCC warrants further investigation.

Objectives

To investigate the prognostic value of endometriosis in patients with stage I ovarian clear cell carcinoma (OCCC).

Methods

The medical records of patients with stage I OCCC who had undergone complete staging surgery followed by systemic chemotherapy were retrospectively reviewed.

Results

A total of 237 women were included in this study. Univariate analysis revealed that the patients with endometriosis-associated ovarian carcinoma (EAOC) had significantly improved recurrence-free survival (RFS) and overall survival (OS) than those without EAOC (5-year RFS: 91.4% vs. 73.0%, respectively, and 5-year OS: 97.5% vs. 89.9%). However, EAOC was not identified as a significant prognostic predictor in multivariate analysis. The potential risk factors determined to be associated with EAOC included the pretreatment CA-125 level, FIGO stage, lymphovascular space invasion (LVSI), and menopausal status (P < 0.001, P = 0.0031, P = 0.020, and P = 0.038, respectively).

Conclusions

Endometriosis was not independently associated with the prognosis of the OCCC patients, even when the tumor was confined to stage I. However, the intrinsic relationship between endometriosis and OCCC warrants further investigation.

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