Two novel sequence variants in MSH2 gene in a patient who underwent cancer genetic counseling for a very early-onset (clear cell) epithelial ovarian cancer Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Friday, October 21, 2016

Two novel sequence variants in MSH2 gene in a patient who underwent cancer genetic counseling for a very early-onset (clear cell) epithelial ovarian cancer



Two novel sequence variants in MSH2 gene in a patient who underwent cancer genetic counseling for a very early-onset epithelial ovarian cancer | Hereditary Cancer in Clinical Practice | Full Text
 

Discussion

Cancer genetic counseling should be always offered during the work-up of young patients with epithelial ovarian cancer, in order to screen the presence of a hereditary syndrome and to improve the oncological follow-up including intensified surveillance. Clinicians should be particularly careful to the evaluation of a positive family history of cancer, being ovarian cancer involved in three different syndromes, such as site-specific, HBOC and Lynch Syndrome.

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