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abstract
Background: The purpose of our study was to
characterize the causes of death among cancer patients as a function of
objectives: (I) calendar
year, (II) patient age, and (III) time after
diagnosis.
Patients and Methods: US
death certificate data in SEER Stat 8.2.1 were used to categorize cancer
patient death as being due to index-cancer, non-index-cancer,
and non-cancer cause from 1973 to 2012. In
addition, data were characterized with standardized mortality ratios
(SMRs), which
provide the relative risk of death compared to all
persons.
Results: The greatest
relative decrease in index-cancer death (generally from > 60% to <
30%) was among those with cancers of the
testis, kidney, bladder, endometrium, breast,
cervix, prostate, ovary, anus, colorectum, melanoma, and lymphoma.
Index-cancer
deaths were stable (typically > 40%) among
patients with cancers of the liver, pancreas, esophagus, and lung, and
brain.
Non-cancer causes of death were highest in patients
with cancers of the colorectum, bladder, kidney, endometrium, breast,
prostate, testis; > 40% of deaths from heart
disease. The highest SMRs were from non-bacterial infections,
particularly among
< 50 year olds (e.g. SMR > 1,000 for
lymphomas, p < 0.001). The highest SMRs were typically within the
first year after cancer
diagnosis (SMRs 10 - 10,000, p < 0.001).
Prostate cancer patients had increasing SMRs from Alzheimer's disease,
as did testicular
patients from suicide.
Conclusion: The risk of death from index- and non-index-cancers varies widely among primary sites. Risk of non-cancer deaths now surpasses
that of cancer deaths, particularly for young patients in the year after diagnosis.
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