Germline and somatic multi-gene sequencing in patients (pts) with advanced high grade serous ovarian cancer (HGSOC) and triple negative breast cancer (TNBC) Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Tuesday, November 29, 2016

Germline and somatic multi-gene sequencing in patients (pts) with advanced high grade serous ovarian cancer (HGSOC) and triple negative breast cancer (TNBC)



Germline and somatic multi-gene sequencing in patients (pts) with advanced high grade serous ovarian cancer (HGSOC) and triple negative breast cancer (TNBC)

Conclusions: Comprehensive germline and tumor analysis with 52 gene panel in advanced HGSOC and TNBC found previously unidentified GPV in 9% of pts and somatic mutations in HR genes in 14% of germline WT pts. This increases options for targeted therapeutics with investigational agents, such as PARP inhibitors. 

GPV = germline pathogenic variants

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