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Is there a relationship between objectively measured cognitive changes in patients with solid tumours undergoing chemotherapy treatment and their health related quality of life outcomes? A SYSTEMATIC REVIEW (abstract)
Objective
This
systematic review examines whether there is a relationship between
objective measures of chemotherapy-related cognitive impairment in
patients with solid cancer tumours and health related quality of life
(HRQoL).
Methods
Multiple
online databases were searched (including Ovid MEDLINE, EMBASE,
PsycINFO, PsycARTICLES, CINAHL, PubMed and Web of Science) in order to
identify articles published between 1980 and 2016 examining the extent
of chemotherapy-related cognitive deficit and its relationship with
HRQoL in cancer patients. Of 2769 potentially relevant articles, 17 studies met the inclusion criteria for the current review.
Results
Evidence
for the presence of cognitive impairment in patients treated with
chemotherapy was found in 15 of the 17 studies. Out of the 15 studies
finding some sort of cognitive impairment, 12 were in female breast
cancer patients, 2 in bowel cancer, and 1 each in ovarian and lung
cancer. Three of the 15 studies found a significant relationship between
various objectively measured cognitively impaired domains and specific
HRQoL outcomes. There was, however, only limited testing of the
relationships between quantifiable cognitive dysfunction and HRQoL
domains.
Conclusions
This
review suggests that in patients with solid tumours, where there is a
relationship between chemotherapy treatment and cognitive impairment,
the type and level of cognitive decline does not consistently appear to
have an impact on such patients’ HRQoL. This could be partly explained
by variations in study design, measures used, definitions of cognitive
impairment, varying measurement time frames, small sample sizes and
differences in disease severity and type of treatment regimes.
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