OA: Commentary: Mendelian randomization analysis identifies circulating vitamin D as a causal risk factor for ovarian cancer

Commentary: Mendelian randomization analysis identifies circulating vitamin D as a causal risk factor for ovarian cancer

 

In summary, Ong et al. present evidence for a causal role of low levels of circulating vitamin D in overall and high-grade serous ovarian cancer, using two-sample MR methodology.¹ Circulating vitamin D levels are modifiable and supplementation may hold potential for ovarian cancer prevention strategies; therefore, further work is needed both to replicate findings presented in this analysis and to help elucidate the mechanisms by which circulating vitamin D may influence ovarian cancer.

 

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study Int. J. Epidemiol. (2016) 45 (5): 1619-1630 first published online September 4, 2016 doi:10.1093/ije/dyw207
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