OA: Debated Role of Ovarian Protection With Gonadotropin-Releasing Hormone Agonists During Chemotherapy for Preservation of Ovarian Function and Fertility in Women With Cancer

Debated Role of Ovarian Protection With Gonadotropin-Releasing Hormone Agonists During Chemotherapy for Preservation of Ovarian Function and Fertility in Women With Cancer

....Although the study by Demeestere et al³ was unable to demonstrate ovarian protection with GnRHa during chemotherapy in patients with lymphoma, this was an underpowered and exploratory analysis of a study in which both control and experimental arm patients received hormonal treatment and in which the end point was flawed. Hence, these results should be considered as exploratory and do not refute findings from well-designed large RCTs on this topic.

Although embryo or oocyte cryopreservation is the first choice for fertility preservation, GnRHa during chemotherapy remains an option for women interested in preserving ovarian function and fertility.