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The association between timing of initiation of adjuvant therapy and the survival of early stage ovarian cancer patients – An analysis of NRG Oncology/Gynecologic Oncology Group trials
Highlights
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- Early initiation of chemotherapy was not associated with improve survival.
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- Age, stage, cytology were prognostic factors in early stage ovarian cancer
Objectives
To determine the association between timing of adjuvant therapy initiation and survival of early stage ovarian cancer patients.
Methods
Data
were obtained from women who underwent primary surgical staging
followed by adjuvant therapy from two Gynecologic Oncology Group trials
(protocols # 95 and 157). Kaplan-Meier estimates and Cox proportional
hazards model adjusted for covariates were used for analyses.
Results
Of
497 stage I–II epithelial ovarian cancer patients, the median time
between surgery and initiation of adjuvant therapy was 23 days
(25th–75th%: 12–33 days). The time interval from surgery to initiation
of adjuvant therapy was categorized into three groups: < 2 weeks,
2–4 weeks, and > 4 weeks. The corresponding 5-year recurrence-free
survival rates were 72.8%, 73.9%, and 79.5% (p = 0.62). The 5-year overall survival rates were 79.4%, 81.9%, and 82.8%, respectively (p = 0.51; p = 0.33
- global test). As compared to < 2 weeks, the hazard ratio for
recurrence-free survival was 0.90 (95%CI = 0.59–1.37) for 2–4 weeks and
0.72 (95%CI = 0.46–1.13) for > 4 weeks. Age, stage, grade, and
cytology were important prognostic factors.
Conclusions
Timing of adjuvant therapy initiation was not associated with survival in early stage epithelial ovarian cancer patients.
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